INTRODUCTION: Maxillofacial bone defects occur for various reasons as infections, tumor and cysts or physiologic loss of bone after extraction of teeth. There are a lot of controversies among dental practitioners in the material used for filling of bone defects to increase the volume of bone in favor of good placement of the implant. Autogenous bone is the gold standard for bone reconstruction due to osteogenic, osteoinductive, and osteoconductive properties. OBJECTIVES: The aim of this study was to evaluate clinically and radiographically the efficiency of using maxillary tuberosity as a block bone graft for augmentation of anterior maxillary defects. MATERIALS AND METHODS: Twelve patients with anterior maxillary bone defects were treated with bone graft harvested from the maxillary tuberosity with an age range of 20 and 50 years old. Piezotome 2 was used for bone harvesting from the tuberosity. Osteosynthesis microscrews were used to fix the block graft in place. RESULTS: Bone density and width showed statistical significant difference detected by cone beam computed tomography (CBCT). CONCLUSIONS: The large and accessible maxillary tuberosity is a reliable source to use as autogenous bone block for augmentation of jaw defects