INTRODUCTION: The quality of the implant surfaces is one of the major factors that influences wound healing at the implantation site and subsequently affects osseo-integration. OBJECTIVES: Evaluation of the osseo-integration around nano-structured dental implant and around sandblasted type histologically. MATERIALS AND METHODS: This experimental study was done on 6 healthy mongrel dogs, all dogs were healthy as documented by a veterinarian report, and kept under the same nutritional and environmental conditions in the animal house at the Physiology Department, Faculty of Medicine, Alexandria University. All dogs were divided into 2 groups: group A received nanostructured dental implant in the left side, group B received sandblasted dental implant in the right side. Afterwards the dogs were sacrificed at 3 and 6 weeks after implant insertion. RESULTS In group A the osseo integration of all implants was noted. New bone formed in direct contact with the implant surfaces and the threads. But in group B one experimental animal preserved the implant in its place while the others were displaced from the bone with fibrous tissue interface. CONCLUSIONS: There is significant increase in the bone healing around nano dental implants as opposed to sandblasted implants.