INTRODUCTION: There is a variety of treatment modalities for oroantral defects based on repair of soft tissue component only of the defect. However, bone regeneration is needed to allow for later restoration of the missing tooth. OBJECTIVE: The aim of this study was to evaluate the efficacy of zirconia porous scaffold in oroantral defects. MATERIALS AND METHODS: This study was conducted on ten patients suffering from oroantral defects of more than three weeks duration and having a width of at least five millimeters (mm). The patients were treated with placement of a custom made zirconia porous scaffold along with buccal advancement flap after a virtual surface for bone model was reconstructed from the cone-beam computed tomography and printed by stereolithography 3D printing method. RESULTS: Clinically, there was a significant improvement in wound healing in 80% of the cases across the follow up period with only 20% of the patients the wound didn't heal due to infected wound margins and the full scaffold was lost prior to the end of the follow-up period and required further treatment later on. Pain intensity decreased throughout the follow-up period with the maximum pain intensity was only immediately postoperative. Radiographically, there was a significant increase in bone density from the baseline by 41.2 percentage change. CONCLUSION: Zirconia porous scaffold is a biocompatible material that enhances new bone formation in closure of oroantral fistulas through its high porosity and clear interconnected porous surface which are a suitable environment for osteoblastic activity.