INTRODUCTION: Alveolar ridge atrophy following tooth extraction remains a challenge for future implant placement. Post-extraction socket preservation and implant placement are two methods that are used to prevent significant post-extraction bone loss. OBJECTIVES: The aim of this study was to evaluate the role of hyaluronic acid when mixed with autogenous bone graft in alveolar socket preservation for future implant placement. MATERIALS AND METHODS: A split mouth randomized clinical trial was carried out in 10 patients, 20 mandibular extraction sockets of single rooted teeth with age ranged between 25-55 years, 10 sockets were grafted with autogenous bone graft only using Auto-MaxTM bone harvester and the other 10 sockets were grafted with autogenous bone graft mixed with hyaluronic acid (HyadentTM). All sockets were evaluated clinically, radiographically, and histologically (after 2 months, core biopsy was taken before implant placement) then histomophometric analysis and delayed implant insertion were done followed by implant stability assessment. After 4 months, final prosthesis was delivered. RESULTS: Histological evaluation revealed rapid thick bone deposition with many well organized osteocytes as well as osteoblast lining of the bone surfaces in the study group and increased mean area percent of formed bone. Radiographic bone density changes were found to be statistically significant between the two studied groups. (P2= <0.001). CONCLUSIONS: The use of autogenous bone graft with hyaluronic acid appears to be more efficient in osteoconduction when compared with autogenous bone graft alone and could be a promising strategy for preservation of alveolar sockets.