INTRODUCTION: The management of facial trauma is one of the most rewarding and demanding aspects of oral and maxillofacial surgery. Being the most prominent mobile bone of the facial skeleton, mandible fracture occurs more frequently than any other fracture. OBJECTIVES: The aim of this study was to compare the outcomes of treatment by the use of cortical lag screws versus miniplates, in patients who have a fracture in the mandibular symphyseal region. MATERIALS AND METHODS: The present study was conducted on fourteen patients with age ranged from 19-48 years. The patients had mandibular symphyseal region fractures requiring open reduction and internal fixation. The patients were clinically examined postoperatively by assessment of pain, edema, surgical wound, occlusion, teeth vitality and nerve injury. They also were assessed radiographically using orthopantomogram and cone beam computerized tomography (CBCT) to evaluate the adequacy of reduction, healing progression and bone density of the fractured segments. CONCLUSIONS: Cortical screw fixation using the lag screw principle offers the advantages of fixation, using minimal hardware, and achieving inter-fragmentary compression, and associated with minimal pain and edema when considering the treatment of linear symphyseal region fractures.