INTRODUCTION: The etiology of orofacial swellings could be attributed to the presence of inflammation, congenital developmental malformations and neoplasia. Orofacial swellings may occur in the nasal cavities, paranasal sinuses, ear, eye, facial skin, oral cavity and salivary glands. Swellings of the orofacial region include cysts and tumors. Cysts are divided into developmental and inflammatory types. Tumors are divided into benign and malignant types. OBJECTIVES: Perform clinicopathological correlation of orofacial swellings and assess the frequency of incidence regarding age, sex, site, and type of lesion. MATERIALS AND METHODS: A clinicopathological prospective study was conducted on 100 patients suffering from swellings in the orofacial region attending the outpatient clinic of the oral and maxillofacial surgery department. The histopathological examination was done. Statistical analysis was carried out on the tabulated data using (IBM SPSS 20.0) software. RESULTS: It was found that the incidence of all swellings in males was slightly more than females. The incidence of all swellings in the second and third decades of age. The mandible was the most frequently affected site. Using the histological classification of the World Health Organization (WHO), 32% were classified as cysts, 26% as odontogenic tumors, 25% as non-odontogenic tumors, 11% fibro-osseous lesions and 6% as salivary gland tumors. CONCLUSIONS: Cysts are the most common oral swellings, followed by odontogenic tumors. The treatment modalities were: marsupialization, enucleation, resection, segmental mandibulectomy and hemimandibulectomy. Following surgical removal of jaw swelling, the entire surgical specimen should be examined histopathologically