57577

THE EFFECT OF TOPICALLY APPLIED HYALURONIC ACID GEL VERSUS TOPICAL CORTICOSTEROID IN THE TREATMENT OF EROSIVE ORAL LICHEN PLANUS

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Oral medicine

Abstract

INTRODUCTION: Oral lichen planus is a common chronic inflammatory muco-cutaneous disease. Although the cause of oral lichen planus is not well known, T-lymphocyte infiltrate suggests a cell mediated immunological damage to basal cell layer of the epithelium. Its suggested treatment is topical corticosteroid. A promising new treatment for oral lichen planus [OLP] is the topical application of hyaluronic acid [HA], which has shown beneficial effect on wound healing. OBJECTIVES: to evaluate the effect of hyaluronic acid gel in the treatment of erosive oral lichen planus in comparison with topically applied corticosteroids. MATERIALS AND METHODS: a randomized, parallel, controlled clinical study was conducted on twenty patients who were randomly divided into two groups. Group I received topical application of corticosteroid (triamcinolone acetonide) 4-5 daily, for 28 days and Group II was similarly treated using hyaluronic acid 0.2% gel. Subjective symptom and Visual Analogue Scale (VAS) were recorded at base line, after 10 days and at 3 months. The objective sign clinical score was recorded at baseline, 1 and 3 months post –treatment. RESULTS: Both groups showed decrease in the lesion size and symptoms of OLP. The HA treated group showed a significantly higher decrease in the pain score in comparison to the corticosteroid treated group. Regarding the healing score, the corticosteroid group showed superior results than that shown with the HA. CONCLUSIONS: HA 0.2% gel is effective in the treatment of OLP, it resulted in a decrease in symptoms and signs of the disease. HA resulted in more control of pain when compared to topical corticosteroid.

DOI

10.21608/adjalexu.2019.57577

Keywords

Hyaluronic acid gel, topical corticosteroid, Oral lichen planus

Authors

First Name

Mohamed I.

Last Name

Youssef

MiddleName

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Affiliation

-Faculty of Dentistry, Alexandria University

Email

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City

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Orcid

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First Name

Zeinab E.

Last Name

Darwish

MiddleName

-

Affiliation

-Professor of Oral Pathology, Faculty of Dentistry Alexandria University

Email

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City

-

Orcid

-

First Name

Rania A.

Last Name

Fahmy

MiddleName

-

Affiliation

-Lecturer of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University

Email

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City

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Orcid

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First Name

Naguiba M.

Last Name

El Sayed

MiddleName

-

Affiliation

-Professor of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry Alexandria University

Email

-

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

8723

Issue Date

2019-04-01

Receive Date

2019-11-08

Publish Date

2019-04-01

Page Start

57

Page End

63

Print ISSN

1110-015X

Online ISSN

2536-9156

Link

https://adjalexu.journals.ekb.eg/article_57577.html

Detail API

https://adjalexu.journals.ekb.eg/service?article_code=57577

Order

10

Type

Original Article

Type Code

1,057

Publication Type

Journal

Publication Title

Alexandria Dental Journal

Publication Link

https://adjalexu.journals.ekb.eg/

MainTitle

THE EFFECT OF TOPICALLY APPLIED HYALURONIC ACID GEL VERSUS TOPICAL CORTICOSTEROID IN THE TREATMENT OF EROSIVE ORAL LICHEN PLANUS

Details

Type

Article

Created At

22 Jan 2023