INTRODUCTION: Amniotic membrane is the innermost layer of the placenta consisting of a thick basement membrane and an avascular stromal matrix. It can be used as a graft and as a dressing to promote healing. OBJECTIVES: Evaluation of the use of amniotic membrane in cases with keloids in Cervico-facial region. MATERIALS AND METHODS: A clinical study was conducted on 10 patients with keloids. The sample was selected conveniently to fulfill a list of inclusion and exclusion criteria. Then the selected participants have undergone surgical excision of the scar with placement of amniotic membrane under the skin at the excised site and wound closure by primary intention and amniotic membrane was used as a dressing as well. Follow up and clinical evaluation was performed over a period of 3 months using Vancouver Score Scale. RESULTS: Follow‐up data collected 3months after the final treatment revealed decreases in the mean score for the following lesion features. Pigmentation from 1.3 to 1.1; Vascularity from 1.3 to 1.2; Pliability from 3.7 to 2.7 and height from 1.6 to 1.1. CONCLUSIONS: The present study showed that the combination of surgical excision and Amniotic membrane placement can be used as a new alternative in treatment of keloid scars.