INTRODUCTION: Temporomandibular Joint (TMJ) dislocation when condyles travel anterior to articular eminence. It may be reducible or irreducible. Chronic recurrent TMJ dislocation was treated by surgical and nonsurgical methods. Minimally invasive methods include injection of sclerosing agents intra-articular and extra-capsular or botulinum toxin to the surrounding muscles. Prolotherapy is a method of strengthening lax ligaments by injecting various types of sclerosing or proliferant solutions such as ethanolamine oleate 5%, autologus blood and others. It is also known as "ligament sclerotherapy" or "regenerative injection therapy" OBJECTIVES: the study aimed to compare 2 types of prolotherapy (autologous blood & ethanolamine Oleate sclerosing agent) injection in treatment of chronic recurrent temporomandibular joint dislocation. MATERIALS AND METHODS: : this study was parallel, controlled, randomized, clinical trial. The study was conducted at Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt. Thirty patients with chronic recurrent temporomandibular joint dislocation were chosen with certain inclusion and exclusion criteria. Fifteen participants were injected with ethanolamine oleate compared with fifteen patients were injected with autologous blood and were followed-up for six months. The participated patients were assessed at the pre- and post-treatment stages by evaluating pain and mandibular range of motion clinically and radiographically using Magnatic Resonance Imaging (MRI) to evaluate condyle-articular eminence relation in opening and closing mouth. RESULTS: There was no significant difference between both prolotherapies in treating chronic recurrent temporomandibular joint dislocation. CONCLUSIONS: Ethanolamine oleate and autologus blood injection are simple, safe and cost-effective treatment for management of chronic recurrent temporomandibular joint dislocation