Introduction: Rehabilitation of the edentulous posterior maxilla with dental implants is challenging. The deficient alveolar ridge interferes with implant insertion of adequate length placed in the correct position and with the accurate inclination. The maxillary sinus elevation procedure has become an important preprosthetic surgical procedure for bone creation in the posterior maxilla prior to implant placement. The use of PRF during sinus-lift procedures has been advocated for many years. Objectives: This study was designed to evaluate the use of platelet rich fibrin (PRF) following sinus lifting with piezosurgery and simultaneous implant placement. Materials and methods: 7 patients were selected to perform sinus lifting with simultaneous implant placement using PRF as a sole agent and piezosurgery device. Results: Cone beam computerized tomography 6 months postoperatively showed statistically significant increase in bone height and density. The mean of the newly formed bone height was (6.55 ± 1.14 mm). The mean postoperative bone height measured from the floor of the maxillary sinus and alveolar crest was (11.35 ± 0.56 mm). The mean of the newly formed bone density was 507 HU. The mean of the postoperative bone density around the implants after 6 months was (547.71 ± 188.42 HU). The mean marginal bone loss was (0.82 ± 0.25 mm). Conclusion: PRF could be successfully used as a sole agent for bone regeneration in lateral sinus lifting with simultaneous implant placement.