Introduction: Multiple restorative materials with various chemical, mechanical and physical characteristics are used as permanent dental restorations. The appropriate selection of a restorative material is crucial for preserving the occlusal harmony and normal masticatory function. Several aspects during selection of restorative materials should be considered, among which are the wear behaviour and abrasive nature of the restorative materials and natural enamel. Objectives: The study determines the two-body wear and surface roughness measurement, of polymer infiltrated ceramic (Vita Enamic) and pressable lithium disilicate based ceramic (IPS e.max press). Materials and methods: Two-body wear was investigated in custom made tooth wear brushing machine (60,000 cycles, 20 N and 60 cycle/min). The test specimens were divided into two groups, each group consisted of 8 ceramic specimens and 8 enamel cusp antagonists. Quantitative analysis of wear was carried out with subtractive weight loss of all specimens before and after wear test. Surface roughness measurements were evaluated before and after the wear test using a white light interference microscope. The data was collected and statistically analyzed using Mann-Whitney (U) test. Results: Statically significant differences were found for two-body wear, with Vita Enamic samples show lower wear loss than IPS e.max press samples and cause less enamel wear loss. The Vita Enamic showed lower surface roughness and caused less surface roughness to enamel cusp antagonist than IPS e.max press samples. Conclusions: Vita Enamic revealed lower wear loss contributed by terms of weight loss and surface roughness change than IPS e.max press. IPS e.max press contributed to more surface roughness and wear loss of opposing enamel than Vita Enamic.