Introduction: Orbital fracture is a common type of midfacial trauma. Its proper treatment is considered a challenging situation. Otherwise orbital complications; as diplopia, limited ocular motility, enophthalmos, hypoglobus and infraorbital dysesthesia; may occur. Proceed® mesh consists of polypropylene soft mesh encapsulated with polydioxanone (PDS) and layered with oxidized regenerated cellulose (ORC). It is a widely used mesh in hernia repair which is proved to be safe and suitable. The ORC component provides the mesh with some properties differ from other materials. It provides a physical barrier to decrease the adhesion between the mesh and orbital tissue. It is a commonly used hemostatic agent. In addition, it is proved to be antibacterial against many resistant species. The PDS component attaches the ORC with polypropylene soft mesh. Objectives: We aimed in this study to evaluate Proceed® mesh clinically in reconstruction of orbital floor defects in seven patients. Materials and Methods: Indications for intervention were diplopia, enophthalmos, minimal clinical improvement over time under drug therapy, ocular limited motility, dystopia, defect more than 50% of the orbital floor and progressive infraorbital hypoesthesia. The ORC side of the mesh was placed facing orbital soft tissue, while polypropylene side was placed towards orbital bony wall. The follow-up schedule was 3 days postoperatively then once weekly for two weeks and then monthly for 6 months. Results: Clinically, most patients recovered from diplopia, dystopia, ocular restriction and enophthalmos. Two patients had transitory postoperative diplopia (for 1 week), that may be due to postoperative muscle weakness. One patient out of four suffered from preoperative ocular restriction, had no or slight improvement postoperatively. Two patients complained from inflammatory reaction within 2-4 weeks postoperatively, resolved by antiinflammatory and antibiotic administration. Conclusion: The study concluded that Proceed® mesh is a suitable material for orbital floor reconstruction, especially in cases of small to medium defects (< 3 cm 2 )