Critically ill patients frequently experience sleep deprivation, which has detrimental effects such as increased pain perception, impaired cognitive function, and delirium. Aim: Evaluate the effect of implementing nursing interventions bundle on sleep quality and associated delirium among patients at intensive care unit (ICU). Design: A quasi-experimental research design was utilized in this study. Setting: Anesthesia Intensive Care Unit of Emergency hospital affiliated to Tanta University hospital. Subjects: A convenience sampling of 60 adult critically ill patients who admitted to the selected setting and divided into two equal groups; 30 patients in each (control and study groups). Tools; Tool (I) Patient interview schedule, tool (II) Richard Campbell Sleeping Questionnaire (RCSQ) and tool (III) Intensive Care Delirium Screening Checklist (ICDSC) Results: A highly  significant difference was detected between the study and control groups regarding their total  sleep quality after applying the nursing intervention bundle ( P=0.000). The incidence of delirium was 30% in the control group compared to 13.33% in study group at the seventh day of intervention with significant differences (P=0.024). Conclusion: Implementing of nursing intervention bundle can improve sleep quality and decrease associated delirium. Recommendation: Sleep interventions bundle should be integrated into routine care for patients in ICU to promote patient sleep and reduce incidence of delirium.