The psychological effects of COVID-19 offer serious concerns to mental health since they increase levels of fear and concern, which are already high, and because the situation is yet uncertain. Aim of the study: to explore the relation between worries, concerns and psychological wellbeing of patients with covid 19 pandemic. Subjects and Method: Study design: A descriptive correlation research design was utilized. Subject: A convenient sample of 250 patients with covid 19 from inpatient of isolation Department of Elmenshawy General Hospital which affiliated to ministry of health. Study tools: 3 tools were used: Tool 1: Socio-demographic and Clinical Data Structured interview, Tool 2: “Ryff's Scales of Psychological Well-Being, Tool 3: Worries and concerns of patients with COVID- 19. Results: This study revealed that more than half of the studied patients have high level of autonomy, also the majority of the sample have high level of worries and concerns, while the quarter of the sample have average with worries and concerns. Conclusions: it can be concluded that, there was a highly negative statistical significant correlation between total worries and concerns level and total psychological wellbeing level. Recommendations: Further research on developing programs that are needed for a better understanding of relations between worries and concerns and psychological wellbeing of patients with COVID-19