Background: Tibial plateau fractures are a complex group of periarticular fractures require careful evaluation and preoperative planning. Study aimed was to evaluate effect of protocol of nursing care on clinical outcomes of post operative patients tibial plateau fracture internal fixation surgery. Subjects and Method:Subjects:A convenient sample of (60) adult patients who are post operatively tibial plateau fracture internal fixation selected, divided randomly into two equal groups.Two tools used for data collection: Structured Interview Schedule tool, consisted of four parts as follow: patient's bio-socio demographic characteristic and medical data, patient's knowledge assessment sheet, immediately and post-operative patient's care, tool2: consisted of three parts as follow: post operative patient's complications, lab investigation and diagnostic test, and Daily Living Activities Scale.Results showedsignificance improvement in patient' knowledge level about tibial plateau fracture internal fixation. There was a statistically significant difference between the study group pre and post the intervention related to total knowledge and daily living activities level. Study concluded that patients showed an improvement in their knowledge level about tibial plateau fracture internal fixation, complication, lab investigation, and daily living activities. Recommendation:designed and implemented for patient at Orthopedic Department in hospitals to enhance their knowledge about tibial plateau fracture and improve their performance patient should be given information about tibial plateau fracture and working activities.Replication of study using a larger probability sample from different geographical areas, in order to generalize the results