Background: Disc surgeries have seen a remarkable increase in the recent times that requires a prompt intervention of the nursing personnel to maintain the patients' quality of life and return to their normal life. Aim of the study: Evaluate the effect of implementing a protocol of nursing care on clinical outcomes for patients undergoing lumbar spine disc prolapse surgeries. Design and Setting: A quasi-experimental research design was used to collect data from neurosurgery departments at Main Tanta university hospitals. Sample: A convenience sampling of (60) patients who were undergoing lumbar disc prolapse surgeries in the previously mentioned settings. They were divided into two equal groups; study and control; each group consisted of (30) patients. Tools: Three tools were used for data collection, Tool (I); Structured Interview Schedule, Tool (II); Neuro-Vascular Assessment Tool, Tool (III); Post Lumbar Disc Surgery Clinical Outcomes Assessment Tool. Results: the main results revealed that there was a high significant improvement in the total levels of knowledge, neuro-vascular assessment, level of pain and Oswestery Disability Index among study group patients at the 2nd and 3rd week post the protocol of care compared to the control group. Conclusion and Recommendation: The implementation of protocol of nursing care had an effect on increasing the level of patients' knowledge, reducing the level of pain post-surgery and so improving ADLs among study group patients. It was recommended that nurses should follow rehabilitative nursing program as a routine care for patients undergoing discectomy surgery.