Background: Cancer is one of the leading causes of death globally and palliative care is an integral component of the comprehensive care for patients in oncology. It is improving the quality of life. The aim of the study: was to assess the family caregivers' needs of patient with cancer regarding palliative care. Subjects and Method: Design: Descriptive study design was utilized in this study. Setting: This study was conducted in Oncology Outpatient Clinic of Tanta Health Insurance Hospital at Tanta city. Subjects: Simple randomized sampling of 400 family caregiver of patient with cancer who attended the previous setting. Tool of the study: Structured interviews schedule was used to collect the necessary data it composed of three parts. Part 1: Socio-demographic characteristics of the family caregivers. Socio-demographic characteristics and medical history of cancer patient. Part 2: Needs of the family caregivers about the palliative care and consisted of five types of needs (Informational, financial, Physical, Psychological and Social) Result: 46.8 % of the family caregivers had high need level for information, while 47% of them had high financial need level for palliative care and 44 % of them had low physical needs level. Moreover 58.3% of them had high psychological needs, and (70 %) of them had high social needs level about palliative care. Conclusion and Recommendations: Most of the family caregivers had high and moderate total needs level about palliative care: Therefore, community health nurse should provide special educational programs to all family caregivers to upgrade their knowledge about palliative care