Background: Hemodialysis is a lifesaving chronic therapy for an increasing number of patients with end-stage renal disease (ESRD), and family caregivers of hemodialysis patients are the first and most crucial source of care at home. Aim of study: Evaluate the effect of an education intervention based on family-centered empowerment model on the quality of life of hemodialysis patient and their caregivers. Subjects and Method: Study design: Quasi-experimental design was used. Study setting: The study was conducted at dialysis unit at Tanta University Hospitals and Kafr El- Sheikh University Hospital. Study subjects: A random sample of 60 patients with chronic renal failure and their caregivers. Tools of data collection: For patients: - Tool I: - A structured questionnaire schedule was used to carry out this study, Tool II: Chronic Kidney Disease SelfEfficacy Instrument, Tool III: World Health Organization Quality of life-BREF. For caregivers:- Tool IV: A Structured interview schedule , Tool V: Scale of General Self-Efficacy for measuring Caregiver Self –Efficacy, Tool VI: Zarit Burden Interview, Tool VII: The Adult Carer Quality of Life Questionnaire Results: There was a significant improvement in total quality of life of the studied patients post implementation of intervention program with highly statistically significant difference at (P= < 0.01) between pre, immediate and three months post of intervention program. There was improvement in overall quality of life of the studied caregivers as support of caring percentage (18.3%,56.7% and 50% respectively) in pre, immediate post and three months post intervention program. Conclusion: The educational intervention program based on family centered empowerment model was effective and quality of life of the studied hemodialysis patients and their caregivers were improved after implementation of the program. Furthermore, a significant improvement was observed in overall quality of life among the studied hemodialysis patients and their caregivers throughout the study phases. Recommendations: Educational intervention programs based on family centered empowerment model should be established in all hemodialysis units.