Background: In a fast changing environment, managers play a crucial role in delivering effective leadership. Servant leadership is one of the most effective leadership styles in the healthcare field. Servant leadership prioritizes the professional growth of staff nurses through listening empathetically, empowering them, and addressing their needs. It is critical in assisting staff nurses in effectively adapting to career changes and improving their job embeddedness. Aim: The aim of the present study was to examine the association between servant leadership, career adaptability and job embeddedness among staff nurses at Main Mansoura University Hospital. Methods: A descriptive correlation design was utilized. Sample of the study consisted of all nurses working at Main Mansoura University Hospital (n=151 staff nurses) who fulfills the criteria of having a minimum of one year experience were included in the study. Three tools were utilized for data collection, namely; Servant Leadership Survey (SLS), Career Adaptability Scale (CAS) and Job embeddedness Scale (JES). Results: Major findings of the present study were positive correlation between servant leadership and staff nurses' career adaptability. Also, there were statistically significant positive correlation between servant leadership and staff nurses‟ job embeddedness. Additionally, there were statistically significant positive correlation between staff nurses‟ career adaptability and their job embeddedness. Conclusion: It was concluded that servant leadership dimensions have significant roles in developing and enhancing both staff nurses‟ career adaptability and job embeddedness. Career adaptability also plays an important role in improving staff nurses‟ job embeddedness. Recommendation: It was recommended that, establishing work environment that supports the benefits of servant leadership and its impact on the career adaptability and job embeddedness of staff nurses