Background: On today´s competitive market, talent management is the basic driving force for the organization to be successful in the face of globalization; organizations are concerned with how to design the talent management strategy that fits the national context. The study aimed to evaluate the effect of a designed program of talent management for nursing managers on nurse's work effectiveness. Subjects and Method: Research design: A–Quasi-experimental design was used in the study. Setting: The study conducted at Sohag University Hospital which provides a health service at Upper Egypt. Subjects: Convenient sample consisted of (25) nursing managers and (235) nurses supervised by nursing managers under the current study. Tools: three tools were used: 1) Demographic data sheet 2) talent management questionnaire, and 3) Work effectiveness questionnaire. Results: About 72% of nursing managers had low level of talent management skill pre intervention, while 64% had high level post intervention and 60% of them had high level with follow up. About 72% of nurses had low level of work effectiveness pre intervention; while 68% had high level post intervention and 64.60% of them had high level with follow up. Conclusion: There are a highly statistically significant differences and positive correlation between all domains of talent management and work effectiveness at post intervention (p < 0.01**). Recommendations: Improve the efficiency of nursing managers to ulilize available talents and experiences, and use different talent management strategies to retain competent employees