Background: Psychiatric constituencies are stressful environments. Resilience can help psychiatric nurses manage with their occupational stress. Resilience is positive adaptations to nurses stress management capacity as well as optimistic life orientation, they will become more productive, creative, and supported. Aim: The study intended to evaluate the effect of resilience program to enhance optimism level among nurses caring for clients with psychiatric disorders Subjects and Method: One- group quasi-experimental design with pre-post evaluation was used. The study sample consisted of twenty nurses working in the psychiatric health and addiction treatment hospital in Port Said City. The data was collected through the two tools include the ego resilience scale and revised life orientation test were assessed before the education program and immediately after finishing the program. The results revealed that there was a statistical significant improvement between high level of resilience in pre/ post program. Also found that, optimism and resilience share a positive relation after the intervention with marital status, educational level and experience in psychiatric nursing. A statistically significant positive correlation between nurses levels of resilience with optimisms in the post program. Conclusion: The program had “great positive effect" on increasing the level of optimism among nurses accomplished the educational session, who caring for psychiatric patients. Recommendations: The findings of the study clearly show that resilience program is effective to boost resilience and optimism