Background: Premenstrual syndrome (PMS) may adversely affect physical and social activities of women's lives and their quality of life (QOL). Thus, understanding health-related QOL of

 

adolescent nursing females affected with PMS is so more essential. Aim: to assess the effect of premenstrual syndrome among adolescent nursing female students on their quality of life. Design: A descriptive research design. Setting: This study was conducted at Faculty of Nursing, Tanta University. Subjects: A convenience sample of 446 female nursing students was taken from the first and second academic grades at the academic year 2019-2020. Tools: Two tools were used. Tool I: An assessment questionnaire sheet: It consisted of two parts as follows: Part (1): Bio- socio demographic characteristics of female nursing students: A) Socio-demographic characteristics of female students and B) Menstrual history of female students. Part (2): Personal experience of the female students regarding premenstrual syndrome. Tool II: WHO Quality Of Life (WHOQOL-BREF) questionnaire. Results: More than two thirds of the studied females mentioned that they were previously complained of PMS while less than one third of them had no previous PMS. Most of them had poor QOL as a result of PMS. Conclusion: Negative highly significant correlations were found between the studied females' QOL and their total level of PMS. Recommendations: Health education programs about PMS and its coping behaviors should be conducted for adolescent and nursing female students to improve their QOL.