Background: Nurses working in intensive care units (ICU) confront several problems resulting from the complexity of patient care, work overloads, time constraints, and administrative responsibilities, all of which have an impact on their psychological wellbeing. Aim of the study:Asses levels of cognitive emotional regulation, spiritual intelligence, and occupational stress among critical care nurses, andexplores the relation between cognitive emotion regulations, spiritual intelligence with occupational stress.Subjects and Method:Study design: A descriptive correlational design. Setting and subjects: The study was conducted in Intensive care units at Tanta Universal Teaching Hospital. Subjects: It involved all available of critical care nurses that are working in the previous settings, their number was 130 nurses. Study tools:It consisted of three tools, tool one was structure questionnaire, itinvolved two parts: socio-demographic data was developed by researchers, andCognitive EmotionRegulation Questionnaire,it was developed by Garnefski. N and Kraaij.V(2001). Tool two wasSpiritual Intelligence Selfreport Inventory, it was developed by King. D, Decicco.T (2008).Tool three was Expanded Nursing Stress Scale, it was developed by French S et al (1999).Results:Nearly half of the participants (45.4%) perceived moderate level of occupational stress, and 39.2% have higher level, regarding to cognitive emotional regulation, 40,8 %of them have moderate level , and 44.6% have lower level. Moreover 46.9 % of the nurses have moderate level of spiritual intelligence and 30.8% have lower level. Thereare negative correlations between cognitive emotional regulations, spiritual intelligence with occupational stress.Conclusion:Increased cognitive emotional regulation and spiritual intelligence among critical care nurses lead to decrease their occupational stress. Recommendation: Establishing training program for critical care nursesto improve their cognitive emotional regulation, and their spiritual intelligence fordeceasing theiroccupational stress.