Background: Considering the benefits of breastfeeding and the insignificant role of breast milk in the transmission of respiratory viruses, the mother can continue breastfeeding, while applying all the necessary precautions, subject to medical advice. Aim: This study aimed to evaluate the effect of precaution guidelines on knowledge, attitude, and practice of breastfeeding women during COVID-19. Subjects and Methods: Research design: a quasi-experimental (one-group pretest/posttest) research design was utilized to accomplish the aim of this study. Setting: The study was carried out at maternal and child healthcare center in Beni Suef City. Subjects: The study included a convenience sample of 80breastfeeding women. Tool: Three tools used for data collection including a structured interview schedule, a reported practice sheet, and attitude rating scale. Results: Out of 80 studied breastfeeding women, 18.80% had good knowledge score pre-intervention, compared with 87.50% post-intervention. Also, 23.70% of them had satisfactory practice pre-intervention, versus 90% post-intervention. Additionally, 25% had a positive attitude related to COVID-19 pre-intervention, compared with 81.30% post-intervention. Prominently, there were a statistically significant differences related to studied women knowledge, attitude, and practice at p < 0.01. Conclusion: These guidelines proved its effectiveness in improving breastfeeding women knowledge, attitude, and practices in the context of COVID-19.Recommendations:Precaution guidelines on COVID -19 pandemic should conducted at breastfeeding mothers attending on Maternal and Child Health Care Centers in Egypt