Coronary artery disease is the leading cause of death globally and the most common type of heart disease. Health complaints are subjective in nature; it may afford information on the degree of recovery from coronary artery disease. Educational guidelines play a vital role in increasing knowledge, practice, and modifying health behaviors. This study aimed to evaluate the effect of educational guideline adherenceon health complaints and anxiety level among patients with coronary artery disease. Subjects and Method: Design: Quasi-experimental research design. Setting: The study was conducted at cardiology and coronary care unit affiliated with El Hussein University Hospitals. Subjects: A Purposive sample of 104 adult patients was selected and equally divided into (52) study and (52) control group. Three Tools includePatients' Structured InterviewQuestionnaire, The Somatic Health Complaints Questionnaire and Beck Anxiety Inventory Questionnaire was used in this study. Results: Themean age of the study and control group were (54.21±8.01& 54.71 ±10.42, respectively), 59.6% of both groups were males. There was a highly statistically significant difference between study and control group regarding total mean scores of knowledge, all dimensions of health complaints and anxiety level scores (p > 0.001) at post and follows up phases throughout implementation. Conclusion: There was a highly statistically significant improvement regarding the mean scores of total knowledge, somatic health complaints and anxiety level for the study group at the post and follow up phases of the educational guidelines Adherence implementation. Recommendation: Develop Telecommunication interventions in secondary prevention for patients with CAD to promote effective reduction of risk factors.