Background: Urinary tract infection is an infection that affects any part of the urinary system. Lack of knowledge and unhealthy behaviors are predisposing factors of recurrent UTI. The study aimed to evaluate the effect of a self-care practice health educational program for patients on urinary tract infection recurrence. Subjects and method: Design: Quasi-experimental research design was used in this study. Setting: The study was conducted in the urology department and the urology outpatient clinic at Tanta University Hospitals. Subjects: Aconvenience sampling of 80 adult patients was divided into two equal control and study groups. Tools: Four tools were used in the study. Tool (1):Structured interview schedule includes two parts, patients' socio-demographic data and patients' clinical data. Tool (II): Patients' knowledge assessment questionnaire. Tool (III):Urinary tract infection assessment tool consists of three-part; risk assessment urinary tract infection recurrence, urinary tract infection manifestation checklist, and laboratory investigations. Tool (IV):Self -Care practice assessment tool. Results: Statistically significant improvements in the total scores of knowledge and self-care practices post-program intervention were found in the study group compared with pre-intervention. The recurrence rate decreased for patients in the study group compared with the control group during follow-up. Conclusion: The educational program was effective for improving knowledge, self-care practices related to urinary tract infection which lead to a decrease in the recurrence rate. Recommendation: Implementation of a continuous educational program for patient self-care practice and preventive behaviors regarding UTI in different geographical areas.