Background: Now a day, social network sites among students become most common. There are different and more advancing types of social network sites and have greater impact on the way the people use of it and have remained major public health issues throughout the whole world. The aim of the study was to evaluate the effect of an educational program on knowledge and uses of social network of students on faculty of nursing at Tanta University. Subjects and Method: A quasi-experimental research design was utilized in this study and it was carried out at Faculty of Nursing, Tanta University. Subjects: The total studied sample was 79 students. Tools of the study: Two tools were used for data collection; tool I: Structured interview schedule consisted of three parts. Tool II: uses of social network sites, this tool was taken and adapted from the instrument developed by Gupta and Bashir in 2018. Results: Total knowledge and uses scores were significantly improved from preprogram to three months after program application for the studied sample, where the mean of total knowledge score increased from 9.25 pre program to 13.39 three months post program and the mean of total uses score increased from 31.47 pre program to 38.54 three months post program Conclusion: The levels of knowledge and uses of the studied sample toward social network were improved after implementation of the educational program. Recommendation: Conducting lectures, workshops and campaigns to raise awareness about correct and accurate information of social network sites and its uses among other students and all community groups.