Background: Acute poisoning is a major health problem leading to emergency department admission and inducing significant patient morbidity and mortality throughout worldwide. Nurse's performance plays an important role in the management of acute poisonings. The aim of the study was to determine the effect of emergent nursing educational intervention on nurses' performance for patients with acute poisoning. Design: A quasi- experimental design was utilized. Setting: The study was conducted at Tanta University Poisoning Control Center (T.U.P.C.C) at Tanta University Hospitals and Elmanshawy General Hospital Emergency Department (E.G.H.E.D). Subjects: All nurses (27) nurses from Tanta University Poisoning Control Center and (10) nurses from Elmanshawy General Hospital) affiliated to ministry of health. Tools: Two tools were used to collect data: Tool (I); Nurses' Structured Interview Scheduled Sheet and tool (II); Nurses' observational checklist about emergent nursing intervention of acute poisoning patient. Results: the present study revealed that there was a significant improvement of studied nurses' knowledge and practice immediate and one month post implementation of educational intervention among both study groups at different setting, where P value P  <0.05 .Conclusion: The study findings revealed that nurses' performance of emergent intervention for patient with acute poisoning was improved after implementation of educational intervention. Recommendation: Developing a system of periodical nurse's evaluation to determine strategies for updating their knowledge and enhancing their practice regarding acute poisoning management.