Acne is a chronic inflammatory disease known to occur in adolescent age group. There are many myths and misconceptions in patients as well as health care providers regarding the causes and treatment of acne Aim: The present study was aimed to evaluate the Effect of Educational Guideline on performance and attitude of blind adolescent students' regarding Acne Vulgaris. Subjects and Method: A quasi-experimental research design was utilized in this study that was conducted at Al-Nour and Al –aml School for the blind, preparatory and secondary of Beni-Suef and El Noor schools of visual handicapped at Tanta city. Convenience sampling of 100 blind adolescent students of the previously mentioned settings. The following study tools were used (pre/posttests): 1) Students' interviewing to assess their knowledge as regards acne vulgaris. 2) An observational checklist to evaluate studied students' practices such as skin care and face massage. 3) Attitude scale to assess adolescent students' attitude regarding acne vulgaris. Results: There were significant differences regarding knowledge, practices (face and skin care, skin massage, methods of drying, hand wash, drinking water, and changing diet, applying topical medications, warm compress and exercises) and attitude about acne vulgaris between pre, post and follow up educational guideline. Conclusion: The present study concluded that, the educational guideline had a positive effect on performance and attitude of blind adolescent girl students regarding acne vulgaris. Recommendations: An orientation program should be prepared for such group of students regarding acne vulgaris. Increasing awareness of blind adolescent students about physical and physiological changes and needs during this stage.