Background:  Advancements in genomic sciences turned the focus of health care from the diagnosis and treatment of genetic diseases to genetic risk identification, genetic counseling and protective actions. This study aimed to assess perception of genetic disorders and genetic counseling among Tanta University students. Design and Setting a descriptive cross-sectional study design. The study was conducted at four Faculties (Faculty of Engineering, Arts, Nursing and Pharmacy) that were selected randomly from medical and non-medical fields in Tanta University. Subjects:  A sample of 13.8% of students in the 4^th academic year were selected (1005 students) by stratified random sample technique. Tool (1): Structured interview schedule developed by the researchers to assess students' knowledge regarding genetic disorders and genetic counseling. Tool (2):Attitude of university students towards genetic disorders and genetic counseling. Results:  77.6% of students had poor level of knowledge, while 87.2% of them showed positive attitude toward genetic disorders and genetic counseling. Three quarters (75%) of students hadn't any information source about genetic counseling. Conclusion: The majority of students had poor knowledge, most of them had positive attitude, and there was a marked lack in the different information sources of genetic disorders and genetic counseling which constituted a major cause behind the deficiency in knowledge. Recommendation:  Integration of modern genetics and genomics into basic and advanced educational programs of Egypt, genetic carrier testing of prevalent genetic diseases in Egypt should made available for university students with accepted costs and adequate coverage.