Adolescence is a critical developmental stage. Blind adolescent girls are a group of disabled girls who needs a special care specifically during the menstruation.The study aimed to examine the effect of audio- drama nursing intervention utilizingpeer education on menstrual hygiene and sickness management among blind adolescents. Design: Quasi- experimental design (pre and posttest) was used to accomplish the present study. Setting: Al Noor institute for visually impaired students at Shebein El-kom City in Menoufia Governorate, Egypt. Subjects: A Convenient sample of 40 blind girls aged between (12-18years) was recruited in this study. Tools: four instruments were used for data collection; I: Structured interviewing questionnaire which consist of two parts; first part:Socio-demographic data; second part: Menstrual data. II: An interviewing questionnaire on knowledge about menstruation; Knowledge about menstrual hygiene questionnaire; andKnowledge about management of menstrual sickness questionnaire. III: Non - observational checklist on practice of menstrual hygiene and management of menstrual sickness. IV: An interviewing questionnaire on satisfaction level. Results: There were lack knowledge and practices regarding menstruation before implementing the audio drama nursing intervention using peer education sessions. Also, there were an improvement and highly statistically significant differences in the totalscores of knowledge and practices of blind adolescent girls regarding menstruation after provision of the audio drama nursing intervention using peer education (P<0.001). Conclusion: The audio drama nursing intervention using peer education were effective in the improvement of the blind adolescent girls' knowledge and practices regarding menstrual hygiene and menstrual sickness management. Recommendation: Continues health education programs should be applied to raise the awareness of blind adolescent girls regarding menstruation in different setting.