Background: The emerging respiratory tract infections (ERTIs) may imply future possible pandemics that present a persistent threat to public health and a huge burden on healthcare services. There is a greater chance for getting ERTIs related to several factors including traditional beliefs and lack of knowledge. Aim: toassess knowledge and beliefs of Tanta university employees regarding ERTIs and its preventive measures based on health belief model (HBM). Design:A descriptive study design was utilized. Settings: five faculties of medical campus that affiliated to Tanta University. Subjects: A Convenience sample of 300 employees working at the previous mentioned settings. Tools: Two tools were used:Tool (I): A Structured interview sheet which included data about bio-socio-demographic characteristics of the studied employees and their knowledge related to the ERTIs and its preventive measures. Tool (II):Beliefs of the studied employees regarding ERTIs based on HBM. Results: More than two fifths of the studied employees had lower level of knowledge regarding the ERTIs and more than half of them had negative beliefs toward ERTIs and its preventive measures. Significant statistical difference was observed between knowledge and beliefs of the studied employees. Conclusion & Recommendations: The study participants had inadequate knowledge and negative beliefs toward ERTIs and its preventive measures. An extensive educational health campaign should be provided to the public to create awareness and positive attitude and beliefs regarding the ERTIs and its preventive measures.