Background: Clinical leadership plays a significant role for emphasizing the responsibility of charge nurses and contribute to developing and empowering their leadership capacity. Competent charge nurse need to be aware of the enablers, opportunities, strategic points and cultures of work environment they were operating. Objective: to study Efficacy of application of clinical leadership competencies program on charge nurses based on self-need assessment. Setting: Tanta Main University Hospital ICUs. Subjects: All (78) charge nurses working at studied ICUs. Tools: Three tools were used, Tool I: Self-assessment of charge nurse development need for clinical leadership skills and capabilities. Tool II: Knowledge assessment on clinical leadership competencies. Tool III: Clinical leadership competency level assessment. Results: Charge nurses 87.2% had high level of needs and importance regarding clinical leadership skills and capabilities development. Preprogram charge nurses 98.7%, 94.9% respectively showed poor level of knowledge and competency of clinical leadership, changed significantly at p < 0.001 post program to be 94.9%, 96.2% respectively. Conclusion: Charge nurses at Main University Hospital ICUs knowledge and competency of clinical leadership were at low level, they were lacking knowledge for developing clinical leadership and have great need for program about clinical leadership competencies to improve their leadership role. Immediately after application of successful clinical leadership competency program, they significantly improved their leadership knowledge and competency. Recommendation: Charge nurses should contribute to clinical leadership development by attendance of formal education programmes, case-conferences, workshops, distance learning, e-learning and self-directed learning.