Background: Needle stick and Sharp injuries pose a high risk to internship nursing students. They represent a major risk factor for transmitting blood borne pathogens as hepatitis B , C virus. Interns being vulnerable section are more prone for these injuries, so they need training module program to improve their skills. Aim: This study was conducted to evaluate the effect of implementing training module on competence of internship nursing students performance regarding needle stick and sharp injuries safety issues. Design: A quasi experimental research design was utilized. Setting: Data were collected from the Faculty of Nursing, Tanta University and Tanta Main University Hospital. Subjects: Random sample of (75) internship nursing students who were spent the internship period at Tanta Main University Hospital. Tools: Three tools were used to collect data: Tool (I); Structure Questionnaire Sheetregarding safety measures about NSI; Tool (II); Observation checklist for students' practice regarding safety measures about NSI. Tool (III): Challenges that affect follow up safety measures. Results: revealed that there were significant improvements in internship nursing students' knowledge and practice regarding safety measures of needle stick and sharp injuries post implementation of training module at P < 0.05. Also, the study revealed that the highest percentages of challenges those affect  their follow up safety measures were; night shifts and lack of training. Conclusion: The study findings revealed that the implementation of training module were successful for improving nursing students' knowledge and practice regarding needle stick and sharp injuries. Recommendations: it is recommended to students instructions should be continually reinforced, and clinical supervision should be managed to ensure compliance in all clinical experiences regarding NSIs.