The advantages of nursing support for cardiac rehabilitation patients can improve the health outcomes and reduce the risk of a new cardiac event through education, support, supervision, and reinforcement .The aim of this study was to assess the effectiveness of home-based-nursing intervention on knowledge, daily living activities and pain for patients after coronary artery bypass graft. Study Design: A quasi experimental research design was utilized. Study Setting: The study was conducted in the out- patient clinics of Mahalla Cardiac Center, Mahalla city, Al-Gharbia Governorate, Egypt. Study Sample: A purposive sample of 140 post- coronary artery graft surgery patients was included. The total sample was divided randomly into two groups study group (70 patients) and control group (70 patients). Study Tools: 1) A structured interviewing questionnaire including; 1) the socio- demographic data of studied patients. 2) Medical data including patient information about present and past history .3) Knowledge assessment data. 4) Barthel Index Scale of measuring activities of daily living (BIS). Study Results: After implementing the Home Based Nursing Intervention, there was high statistical significance improvement in study groups' total knowledge compared to controls. Pain level had significantly improved, as well as daily living activities among study group than control group. Conclusion: Home based nursing intervention was effective in improving patient's knowledge, level of pain and daily living activities after coronary artery bypass graft. Also, it played an important role in improving those patients through tailoring health education about healthy life styles for complete recovery and preventing complications. Recommendations: Nurses have to povide awareness program for educating patients about Home based nursing intervention to prevent complication and attaining complete recovery after coronary artery bypass graft (CABG) surgery