Patient safety is freedom from healthcare-associated, preventable harm. To maintain or improve patient safety, error has to be prevented, rectified or at least minimized. Aim of the study is to determine the perception of patient safety competence among under graduate nursing students. A descriptive research design was used. Setting: Faculty of Nursing Menoufiya University. Sample: convenient sample of 120 fourth year nursing students. Tool for data collection: Health Professional Education in Patient Safety Survey (H-PEPSS). Results: nursing students have moderately competent related to domain of patients safety, There were statistical significant differences between learning in class room and leaning clinical setting related to culture of safety and the total specific patient safety content areas. The mean score is higher in clinical area than in class room. Conclusion: Nursing students have moderate level of competence related to patient safety. Recommendation: patient safety issues must be included in the curricula of undergraduate nursing students.