Orientation programs based on LNA encourage nurse interns to feel safe and enable them to demonstrate competency in the basic clinical and management skills needed for providing high quality and safe patient care. Using LNA ensure NIs commitment to these program. This study aimed to design, implement, and evaluate an orientation program about clinical and management skills needed for nurse interns based on the findings of learning needs assessment tool. Material and method the study was conducted at Tanta University Faculty of Nursing and Tanta University Emergency and Main Hospitals ICUs and obstetric and dialysis departments. (384) nursing students passed the 4th academic year attended the orientation program. (198) spent their internship year at Tanta University Hospitals were included in the researcher's observation 3 month post program. The data collection was achieved by using LNA scale, knowledge test, NIs' orientation program and follow up observation sheet. RESULTS: Pre program around half (51%) of NIs assessed themselves as cannot carryout different clinical and management skills. Majority (87%) of NIs got low knowledge level for both skills. Post orientation program statistical significant improvement at (P≤0.05) was found in NIs' knowledge and practical levels for both clinical and management skills. Conclusion designing orientation programs before starting the internship year based on nurse interns LNA is important to ensure efficient interns performance. Recommendation conduct orientation programs based on nurse interns' LNA and knowledge test before starting internship year and at the beginning of each new rotation, provide nurse interns with pass booklet include standard procedures required to be carried out in each rotation, provide them also with designed evaluation manual based on the pass booklet and implementing nursing mentor-ship and preceptor-ship programs during internship year.