Spirituality affects mental health in a positive way and creates an environment conducive for personal well being. Spirituality is being referred to one of the forgotten dimensions of personal well being and mental health care. It is often described as a mental platform, where one can meet their true self. It is considered a sacred realm of human and self experience. Aim of the Study : to determine the impact of psycho-educational program about spirituality on the quality of life among hospitalized psychiatric patients. Study design : A quasi experimental design was utilized for this study. Setting : The study was conducted at Tanta mental health hospital . Subjects : The subjects of this study consisted of 50 hospitalized psychiatric inpatients , they were fulfilling the following inclusion criteria ; adult aged from 18 to 63 years , psychotic patient not having mystical experiences , able to communicate relevantly and willing to participate in the study. Tools: Three tools were used to collect data A structured Interview Schedule to collect data regarding socio demographic and clinical characteristics of the studied patients , Daily Spiritual Experience Scale and WHO Quality of life instrument. Results : showed that there were significant statistically positive correlation between the total score of quality of life and total score of spirituality among the studied patients pre , immediately , one month and three months post application of the program. The study concluded : The use of spiritual program have a positive effects on quality of life of hospitalized psychotic patients . Recommendations : Awareness and training programs about importance of spirituality for mentally ill patients should be develop and conducted for all psychiatric nurses to participate in the provision of spiritual care .