Management program on nursing staff leading role and compliance to follow safety measures is an important component help to protect nursing staff from work related risks. Goal of safety program is to keep staff nurses safe and lead them toward safety actions, so they can help them to gain knowledge, and skills to deliver safe and quality care. So, the aim of this study was to determine the effect of management program on nursing staff leading role and compliance to follow safety measures at intensive care units. Study was conducted at all ICUs of Tanta Emergency Hospital. The total number of study sample was (n=100) nursing staff working in ICUs at Tanta Emergency Hospital, including charge nurses (n=30) and bedside nurses (n=70). Twoo tools were used for the collection of data: (1) Nursing Staff Performance Scale and (2) Nursing Staff Knowledge Questionnaire. The results of this study revealed that minority (26.7%) of charge nurses showed satisfactory level of practice for leading role pre-program, improved to be majority (86.7%) post-program. Few (41.4%) bedside nurses had satisfactory level of total compliance to follow safety measures practice pre-program, improved to majority (88.6%) post-program. Nursing staff (48%) had poor level of total knowledge pre-program, but the majority (92%) showed good level of total knowledge post program. Conclusion: Nursing staff knowledge and practice on leading role and compliance to follow safety measures in ICUs at Tanta Emergency Hospital were low, change nurses leading role and bedside nurse's compliance practice improved after implementation of needed program. Therefore, the study recommended that conduct regular training programs, workshops and seminars for nursing staff to refresh their knowledge, skills and experiences related to leading role and safety measures.