Background: According to the World Health Organization, every citizen of the world has the right to healthy and safe work; a right to a work environment that enables him or her to live a socially and economically productive life. The hospital infrastructure is the total of all physical, technical and organizational components or assets that are prerequisites for the delivery of health care services. Aim of the study: Assess quality of El-Menshawy General Hospital infrastructure among nursing staff. Research design: Descriptive research design was used in this study. Setting: The study was conducted at El- Menshawy General Hospital departments. Subject: All (530) available nursing staff at the time of data collection .Tools: Tool 1: Nursing staff perception regarding quality of El Menshawy General Hospital infrastructure questionnaire, Tool П:Quality of El-Menshawy General Hospital infrastructure observational checklist. Results: According to them the majority of Nursing staff showed high level of perception regarding neonatal intensive care unit. Also, above fifty percent of nursing staff showed high level of perception regarding emergency room infrastructure, intensive care unit, the facilities and its management, operative room infrastructure, dialysis infrastructure, respectively . According to researcher observation the actual level of quality is high in information technology , neonatal intensive care unit and dialysis infrastructure. Moderate level of quality in technical medical equipment, operative room and facility and its management. While low level of quality in supply facility system. Conclusion: There was significant positive correlation between facility and its management and information technology . Also there was significant positive correlation between disposal system and outreach services. Recommendations: Activation of hospital committee role ( quality committee, health and occupational safety committee, infection control committee and continuous training committee), Provide continuous training program for all nursing staff that improve their performance , increase their knowledge and skills , and motivate them to perform quality patient care.