Empathy is considered a useful skill for psychiatric nurses. It is an essential component of a caring relationship and especially critical to the provision of professional quality of life. The Aim of this study is to assess Psychiatric nurse‟s empathy, burnout and its relation with professional quality of life. This study followed a descriptive design. The present study was conducted at Tanta mental health hospital, 84 nurses. Three tools were used to collect data for the study, Tool 1:t consists of two parts Part 1; a structured interview schedules use to socio-demographic data. Part 2 Interpersonal Reactivity Index (Empathy), Tool II Maslach Burnout Inventory questionnaire and Tool III Professional Quality of Life Scale. The result reveled that there was a significant positive correlation between nurse‟s empathic concern and total burnout score at r=0.575, p=0.00 and significant positive correlation between the nurses‟ compassion satisfaction total score and their personal fulfillment at r=0.319, p=0.003. Conclusion; it was concluded that psychiatric nurses are at high risk for burnout related to imbalance between level of Compassion fatigue and satisfaction that affect the quality of life in addition to the nurses had high level of empathy concern with high level of distress .The study Recommended that the health care professionals realize what the causes and effects of burnout are, seems to be important. It is being planned to carry further, longitudinal research, in which causes of burnout will be investigated as far as correlation with empathy level is concerned. Developing educational intervention program for nurses about the empathy