Background: Chronic rheumatologic disease in children is juvenile rheumatoid arthritis, yet little is known about their health-related quality of life .Aim of the study was to describe Health Related Quality of Life in self-reports of children with juvenile rheumatoid arthritis. Subjects and Method: descriptive research design was used in this study. A convenience sampling technique was used for 100 children aged from8 to 18 years who had been attending to rheumatology unit and rheumatology outpatient clinic at Assiut University Children Hospital. Results: There was a statistically significant impaired in pain and hurt, daily activities, treatment, worry and communication among children with juvenile rheumatoid arthritis. Conclusion: children with juvenile rheumatoid arthritis have lower health-related quality of life. Recommendation: The study recommended that health promotion program for children with juvenile rheumatoid arthritis, and their family members are needed. Nurses, physicians, parents and teachers must be informed of the risk for impaired health-related quality of life among juvenile rheumatoid arthritis children to promote interventions that must improve health outcomes.