Premature rupture of membranes is an obstetric problem with an obscure etiology, difficult to diagnose and is associated with significant maternal and neonatal morbidity and mortality. Its management strategies are diverse and controversial. The aim of this study: was to identify the relationship between premature rupture of membranes and maternal and neonatal outcomes. Subjects and method: The study was conducted at obstetric departments' labor units of two settings; Tanta University hospital and El-Menshawy hospital. A convenient sample of 120 parturient women who fulfilled the inclusive criteria were included in the study. Three tools were used for data collection; Tool (I): A structured interview schedule that included (a). Socio demographic characteristics, (b), Reproductive history, and (c). History of present pregnancy. Tool (II): Maternal outcome assessment observational checklist that included two parts. Part I: assessment of general condition of the women, and Part II: obstetrical and local abdominal examination. Tool (III): Neonatal outcome assessment observational checklist. Results: The results of the present study revealed that there was a significant relation between premature rupture of membranes and the occurrence of maternal and neonatal outcomes. Socio-demographic factors include residence, income; age, educational level, and occupation were risk factors predictors of premature rupture of membranes. History of abortion, and exposure to infection, anemia, strenuous effort/activity, and number of follow up visits were also significant risk factors predictors of premature rupture of membranes. Conclusion: The gestational age in weeks and latent period of premature rupture of membranes were the main determinants of maternal and neonatal outcomes. Prematurity is the principal risk to the fetus with its associated morbidity. On the other hand, infectious morbidity is the primary maternal risk among women. Recommendations: Premature rupture of membranes is one of the most importance obstetric complications that should be focused in the curriculum of basic nursing education as well as continuing education. Additionally, antenatal classes should be planned and developed in order to increase pregnant women's awareness to seek obstetrical care regarding premature rupture of membranes at proper time.