Background:  There is increasing evidence that gastroesophageal reflux induces and aggravates rhinosinusitis. This study aimed to assess the correlation between sinonasal troubles and gastric reflux disease and evaluates the effect of treatment of GERD on improving sinonasal symptoms.
Patients and methods:  In this single-arm (pre and post) Quasi-experimental study, thirty-seven patients with GERD who had sinonasal symptoms defined by the European Position Paper on Rhinosinusitis and Nasal Polyps criteria (EPOS) which gather anterior/posterior rhinoscopy results with patient history, and MSCT findings, received medical treatment for GERD only in the form of PPIs. They were reassessed after one and three months for improvement in their symptoms and its effect on the quality of life (QOL) using 22- items sinonasal outcome test (SNOT22), Modified Lund Kennedy (MLK) scoring system to compare findings in the nasal endoscopy and MSCT findings were subjected to Lund‐Mackay computed tomography score (LMCTS).
Results:  There was a significant improvement in nasal symptoms and signs seen in endoscopic examination and MSCT findings, and the SNOT-22 score was significantly decreased, reflecting patients' satisfaction.
Conclusion:  This study suggests a positive correlation between the presence of gastric reflux and an increased incidence of sinonasal symptoms proved by treatment of gastric reflux only without symptomatic treatment of the nose. PPIs are an effective drug for refractory CRS in patients confirmed to have GERD.