A combined vaccine was constructed to contain FMD 0₁, RVF ZH₅,₀₁ and sheep pox Egyptian strain inactivated with Binary ethylenemine (BEI) and adsorbed on aluminium hydroxide gel. Comparative studies were conducted to evaluate the prepared vaccines (three monovalent FMD, RVF and Sheep Pox separately and the combined one). It was found that the serum neutralization antibody titer of sheep vaccinated with the combined vaccine (FMD and RVF) reached its peak earlier than those vaccinated with each as monovalent vaccine, separately, while, there was no significant difference in efficacy of immune response between combined vaccine and sheep pox vaccine. So, it is recommended that animals should be boostered at the 4^th week post the first dose.