The study examined the effect of dietary fluoride (NaF) and aluminum Al2(SO4)3 on laying hens performance. A total of 108 White Hy-line hens was housed in individually cages (4 hens/cage) and divided into three equal groups. They were fed a diet supplemented with 0 (as control ), 1300-ppm F and 1300-ppm F plus 1040-ppm Al, respectively. The body weight, egg mass, feed consumption, feed conversion, egg quality measurements and blood parameters were taken. It could be noticed that high F intake significantly depressed body weight, egg number,egg weight, egg mass, feed consumption and feed conversion ratio. However, these depressions were not as severe when Al was present in the diet. Also, the depression in performance due to F feeding was not simply due to the depressed feed intake but was a result of metabolic function of F. With respect to blood parameters, it could be noticed that the high F intake significantly decreased hematoait level, plasma calcium and phosphorus. However, dietary Al minimized the effect of high fluoride toxicity It could be concluded that the fluoride levels in plasma , liver , kidney and tissues were significantly increased when the 1300 ppm F diet was fed. Also, the kidney contained more fluoride than the liver or musde . The addition of Al to 1300 ppm F diet reduced the fluoride level in plasma , muscles and kidney.