The present work aims to study the susceptibility of thirteen Egyptian wheat grain varieties to infestation by the lesser grain borer, Rhizopertha dominica F. and khapra beetle, Trogoderma granarium Everts. Basis of evaluation were growth index. percent weight loss, damage and germination (%). The obtained results showed significant differences among the tested varieties. In respect to R.dominica eight varieties: Sakha 69. BenlSwalf 1, Sohag 3. Gemmiza 7, Giza 164, Soahag 2, Sids 1 and Beni Swaif 3 were found to be the least susceptible based on growth index. The other varieties were found to be the most susceptible (Giza167, Sohag Duruml, Giza 163, Giza 168, Sakha 93). Germination (%) and weight loss (%) were 59% and 31.1% in the least susceptible variety (Sakha 69) respectively, while reached 6.0% and 42% in the most susceptible variety (Sakha 93). In case of T.granarium, eleven varieties were the most susceptible (Gemmiza 7, Sohag 3, Sohag Durum1, Beni Swaif 3, Giza 168, Sakha 69, Beni Swaif 1, Sohag 2. Sids 1, Giza 164, Giza 167) varieties based on values of the susceptibility index. The other two varieties (Sakha 93 and Giza 163) were the least susceptible or moderately resistant and differ significantly. The study showed that none of the 13 varieties was completely immune to both pests since all the varieties reacted significantly with insect growth. Further studies are still needed to explain factors and reasons of resistance or susceptibility. Other complementary methods of control for safe grain storage are also nopetael