The main goal of the government in the recent time is to realize integrated sustainable agriculture of Southern Valley regions. This forms continuous main support to overcome the environmental problems, decreasing population intensity in the Valley and Nile Delta and redistributes inhabitants to constitute new perfect settlements. The present work aims to study effective of different water amounts as well as nitrogen doses on sesame growth and yield under local climatic conditions. The experimental field is conducted in the farm of Agricultural Research Station at South Valley-Toshky, Agricultural Research Centre. The experiment involved treatments of four amounts of irrigation water (calculated water requirement is 2941 m3/fd) distributed by sprinkler irrigation system daily as well as three doses of nitrogen fertilizers for sesame with four replicates in split plot design. The soil profile is shallow. The total calcium carbonate percentage changed from area to another, it varies from 10% to 16%. Therefore, it needs a good irrigation management to protect root system from damage. The soil salinity is low; p1-1 ranged between 8.9 and 9.2. The soil fertility is different from part to another. Except iron and potassium, the soil fertility is low in most studied macro. and -micronutrients. Moreover, the soil is low in organic matter, less than 0.5%, due to the dry conditions. For sesame plant, results of yield indicate that except capsules number, the studied plant parameters responded to the application of irrigation water in this area. The results of the statistical analysis indicate that the plant height and weight of plant are significantly affected by application of water irrigation. The capsules number of sesame did not show any significant response to water application. Seeds weight and total yield are highly significantly affected with irrigation amount treatments. It could be recommended that using low nitrogen dose combined with less water application treatment gives a better seed yield in Toshky.