Two field experiment was conducted during the summer 2019 and 2020 summer seasons at Giza Research Station, Agricultural Research Center , to study the effectiveness of some herbicides on weeds control and their effect on sesame. Cultivar Shandaweel3, was used. The experiment was laid out in randomized complete block design with four replications included ten weed control treatments (alone or followed by one hand hoeing, hand hoeing twice and unweeded check). The resulted from this study pointed that the two field experiments were high infestation by 36.9 and 36.7 ton/fed., in both seasons, which reduced sesame yield about 16.1 and 19.9 % compared to hand hoeing twice and about 29.7 and 33.5 % compared to the application pendimethalin followed by with one hand hoeing, which produced the highest sesame seed yield and the highest reduction percent of total weeds. Metribuzin alone and or followed by with one hand hoeing produced the best reduction of total weeds without any significantly different in hand hoeing twice, but gave the lowest one of sesame seed yield compared to other weed control treatments under study due to it herbicide caused phytotoxic effect on the sesame crop. Prometryn alone or followed by with one hand hoeing was the lowest treatment on reduced fresh weight of total weeds. Clethodim alone was resulted the lowest reduction on fresh weight of total weeds, due to clethodim specific herbicide of grassy weeds.From this study can be using pendimethalin or hand hoeing twice for weeds control in sesame field.