Current study has focused on the hypothesis that augmentation of organic fertilizers with lignocellulolytic fungi could overcome the slow-release issue of nutrients and act as plant growth-promoting fungi (PGPF) for plants against synthetic fertilizers. Two factorial experiments were implemented to study the influence of compost, processed by the addition of lignocellulolytic fungi, against rates of NPK fertilizers on the growth and productivity of cultivated wheat in sandy soil. An inoculum consisted of two cellulolytic fungi, viz Trichoderma harzianum and Trichoderma viride ‎and a ligninolytic fungus, viz Phanerochaete chrysosporium, was used for processing the compost before sowing. Three rates of NPK fertilizers, viz 100%, 75%, or 25% of the recommended dose were combined with processed compost or unprocessed. The results revealed an intensification of overall microbial count and associated activities in the rhizosphere of plants due to processed compost and a medium dose of NPK fertilizers. The dry weight of shoot generally increased in order ‎‎100% NPK> 75% NPK > 50% NPK, with a non-significant difference between 100% ‎and 75% treatments when combined with processed compost. Despite the superiority of the full dose of NPK treatment, the divergence between them and ‎‎‎75% NPK fertilizers appeared non-significant when combined with processed ‎‎compost for straw and grain yield, the weight of 1000 grains, or crude protein. Under the current situation, empowerment to ‎diminish the applied amount of synthetic NPK fertilizers by 25% from the total dose by the incidence of saprobic fungi for ‎more decomposition of organic matter doing a positive priming effect in wheat rhizobiome acting to improve the above- and below-ground parts of plants as a source capacity for high grain yield in eco-friendly and sustainable sound.